Curcumin has been used as an edible health-promoting substance for thousands  of years as part of traditional medicinal practices  in Asia. More recently,  modern  scientific  methods  have demonstrated that curcumin exhibits a broad spectrum of biological activities  that may be beneficial to human health, including antioxidant, antimicrobial, anti-inflammatory, and antitumor activities. Even so, there are a number of challenges that have  to be addressed when  formulating curcumin-based functional foods or therapeutics,  including its low water solubility, chemical  stability, and bioavailability. In this article, we highlighted some of the methods  that can be used to overcome  these problems, including antioxidant,  encapsulation, and  storage  strategies.   In  particular, we  focused on  the  utilization of colloidal delivery systems, such  as micelles, liposomes, microemulsions, emulsions, solid lipid nanoparticles, biopolymer particles, and  nature-derived colloidal particles. Each  of these delivery systems has its own  advantages and  disadvantages for specific applications and  it is important to select the most appropriate formulation. For instance, there are differences in the appearances, textures, mouthfeels,  flavors,  shelf-lives, and environmental histories  of different curcumin-fortified functional food products (such as soft drinks, milky drinks, sauces, dressings, and bakery  goods),  which require different kinds of encapsulation technologies. In the future, it will be important to compare  different formulations in terms of their cost, ease of manufacture, robustness,  pharmacokinetics, bioavailability, bioactivity, sustainability, and  environmental impact. The  most  suitable formulation for a specific application can then be selected.

 

Funding:  This  material was partly  based upon work  supported  by the National Institute of Food and Agriculture, USDA, Massachusetts Agricultural Experiment Station (Project Number 831) and USDA, AFRI Grants (2016-08782).

Acknowledgments: This  material  was partly based upon  work  supported by the National Institute  of Food and

Agriculture, USDA, Massachusetts Agricultural Experiment Station (Project Number 831). 

Conflicts of Interest: The authors  declare no conflict  of interest.

Abbreviations

C4-2B                        C4-2 Bone metastatic

  1. coli Escherichia coli
  2. faecalis Enterococcus faecalis

HCT 116                  Human Colorectal Carcinoma cell lines

IL                            Interleukin

LNCaP                 Lymph Node  Carcinoma of the Prostate

NFkB                     Nuclear Factor Kappa B

  1. P. aeruginosa Pseudomonas aeruginosa Rko                            Rectal carcinoma cell line autrus                  Staphylococcus aureus

TNF-a                    Tumor Necrosis Factor Alpha

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